פרופ' שרית סיון

Prof. Sarit Sivan

מוסד עיקרי

המכללה האקדמית להנדסה אורט בראודה

ORT Braude College

דוא״ל

ssivan@braude.ac.il

קורות חייםCV

דיסציפלינות ראשיותMain Disciplines

Medicine - Biomedical Engineering

דיסציפלינות משניותSecondary Disciplines

Biomaterials, Tissue Engineering

תחומי מחקר / מילות מפתחKeywords

Drug delivery

פרסומים ויצירות עיקריים / עדכנייםMain / Recent Publications

Mordechai, HS, Aharonov, A, Sharon, SE, et al. Toward a mechanically biocompatible intervertebral disc: Engineering of combined biomimetic annulus fibrosus and nucleus pulposus analogs. J Biomed Mater Res. 2023; 1- 16
Sivan, S.S.; Bonstein, I.; Marmor, Y.N.; Pelled, G.; Gazit, Z.; Amit, M. Encapsulation of Human-Bone-Marrow-Derived Mesenchymal Stem Cells in Small Alginate Beads Using One-Step Emulsification by Internal Gelation: In Vitro, and In Vivo Evaluation in Degenerate Intervertebral Disc Model. Pharmaceutics 2022, 14, 1179.
Weitz, I.S., Perlman, O., Azhari, H. et al. In vitro evaluation of copper release from MRI-visible, PLGA-based nanospheres. J Mater Sci 56, 718–730 (2021).
Sheskin, T, Geyer, O, Lotan, N, Sara Sivan, S. Controlled and time-scheduled drug delivery: Polyanhydride-based nanoparticles as ocular medication carriers. Polym Adv Technol. 2021; 32( 12): 4851- 4859
Knani, D, Eylon, M, Sivan, SS. Molecular modeling study of the swelling of glycosaminoglycan-analog biomimetics for intervertebral disc repair. Polym Adv Technol. 2020; 31: 2733– 2741. 2020
Benguigui, M., Weitz, I.S., Timaner, M. et al. Copper oxide nanoparticles inhibit pancreatic tumor growth primarily by targeting tumor initiating cells. Sci Rep 9, 12613 (2019).
Z Li, AM Behrens, N Ginat, SY Tzeng, X Lu, S Sivan, R Langer. (2018). Biofilm‐inspired encapsulation of probiotics for the treatment of complex infections. Advanced Materials 30 (51), 1803925
O Perlman, IS Weitz, SS Sivan, H Abu-Khalla, M Benguigui, Y Shaked. (2018). Copper oxide loaded PLGA nanospheres: Towards a multifunctional nanoscale platform for ultrasound-based imaging and therapy. Nanotechnology 29 (18), 185102
Christian E.H. Schmelzer, Marcus B.M. Nagel, Szymon Dziomba, Yulia Merkher, Sarit S. Sivan, Andrea Heinz, Prolyl hydroxylation in elastin is not random, Biochimica et Biophysica Acta (BBA) - General Subjects, Volume 1860, Issue 10, 2016, Pages 2169-2177
M. Alagem-Shafir, E. Kivovich, I. Tzchori, N. Lanir, M. Falah, M.Y. Flugelman, U. Dinnar, R. Beyar, N. Lotan, S.S. Sivan, The formation of an anti-restenotic/anti-thrombotic surface by immobilization of nitric oxide synthase on a metallic carrier, Acta Biomaterialia, Volume 10, Issue 5, 2014, Pages 2304-2312
SS Sivan, E Wachtel, P Roughley. (2014). Structure, function, aging and turnover of aggrecan in the intervertebral disc
Biochimica et Biophysica Acta (BBA)-General Subjects 1840 (10), 3181-3189
SS Sivan, S Roberts, JPG Urban, J Menage, J Bramhill, D Campbell. (2014). Injectable hydrogels with high fixed charge density and swelling pressure for nucleus pulposus repair: biomimetic glycosaminoglycan analogues. Acta biomaterialia 10 (3), 1124-1133
Sivan, S.S., Hayes, A.J., Wachtel, E. et al. Biochemical composition and turnover of the extracellular matrix of the normal and degenerate intervertebral disc. Eur Spine J 23 (Suppl 3), 344–353 (2014).
S Sivan, A Schroeder, G Verberne, Y Merkher, D Diminsky, A Priev. (2010). Liposomes act as effective biolubricants for friction reduction in human synovial joints. Langmuir 26 (2), 1107-1116
SS Sivan, E Wachtel, E Tsitron, N Sakkee, F van der Ham, J DeGroot. (2008). Collagen turnover in normal and degenerate human intervertebral discs as determined by the racemization of aspartic acid. Journal of biological chemistry 283 (14), 8796-8801

מענקים ופרסים | Grants and Awards

Israel Science Foundation - ISF

Novel injectable biomimetic glycosaminoglycan analogues for intervertebral disc regeneration

בשיתוף עם ד"ר מיכל עמית

1,250,000 ₪