ד"ר ערן בוסיס

Dr. Eran Bosis

מוסד עיקרי

האקדמית להנדסה בראודה כרמיאל

Braude College Of Engineering Carmiel

דוא״ל

bosis at braude.ac.il

דיסציפלינות ראשיותMain Disciplines

Bioinformatics, Biotechnology, Computational and Systems Biology, Microbiology, Molecular Biology

תחומי מחקר / מילות מפתחKeywords

Antibacterial toxins, Bacterial secretion systems, Bioreactors, Effectors, Immunity Proteins, Pichia pastoris, Protein Production

פרסומים ויצירות עיקריים / עדכנייםMain / Recent Publications

Mahata, T., Kanarek, K., Goren, M.G. et al. Gamma-Mobile-Trio systems are mobile elements rich in bacterial defensive and offensive tools. Nat Microbiol 9, 3268–3283 (2024).
Mass S, Cohen H, Podicheti R, Rusch DB, Gerlic M, Ushijima B, et al. (2024) The coral pathogen Vibrio coralliilyticus uses a T6SS to secrete a group of novel anti-eukaryotic effectors that contribute to virulence. PLoS Biol 22(9): e3002734.
Kanarek, Katarzyna, Chaya Mushka Fridman, Eran Bosis, and Dor Salomon. "The RIX domain defines a class of polymorphic T6SS effectors and secreted adaptors." Nature Communications 14, no. 1 (2023): 4983.
Joana Costa, Joël F. Pothier, Eran Bosis, Jens Boch, Roland Kölliker, and Ralf Koebnik. 2023. A Community-Curated DokuWiki Resource on Diagnostics, Diversity, Pathogenicity and Genetic Control of Xanthomonads. Molecular Plant-Microbe Interactions
Tchelet, Daniel, Kinga Keppel, Eran Bosis, and Dor Salomon. "Vibrio parahaemolyticus T6SS2 effector repertoires." Gut Microbes 15, no. 1 (2023): 2178795.
Fridman, Chaya & Jana, Biswanath & Ben-Yaakov, Rotem & Bosis, Eran & Salomon, Dor. (2022). A DNase Type VI Secretion System Effector Requires Its MIX Domain for Secretion. Microbiology Spectrum. 10. .
Jana, Biswanath & Keppel, Kinga & Fridman, Chaya & Bosis, Eran & Salomon, Dor. (2022). Multiple T6SSs, Mobile Auxiliary Modules, and Effectors Revealed in a Systematic Analysis of the Vibrio parahaemolyticus Pan-Genome. mSystems. 7. e0072322.
Kanarek, K., Fridman, C.M., Bosis, E. et al. The RIX domain defines a class of polymorphic T6SS effectors and secreted adaptors. Nat Commun 14, 4983 (2023).
Dar Y, Jana B, Bosis E, Salomon D. A binary effector module secreted by a type VI secretion system. EMBO reports. 2021 Jul 29:e53981.
Catara, V.; Cubero, J.; Pothier, J.F.; Bosis, E.; Bragard, C.; Đermić, E.; Holeva, M.C.; Jacques, M.-A.; Petter, F.; Pruvost, O.; Robène, I.; Studholme, D.J.; Tavares, F.; Vicente, J.G.; Koebnik, R.; Costa, J. Trends in Molecular Diagnosis and Diversity Studies for Phytosanitary Regulated Xanthomonas. Microorganisms 2021, 9, 862.
Juvenal Lopez, Nguyen-Hung Le, Ki Hwan Moon Dor Salomon, Eran Bosis , Mario F. Feldman (2021) Formylglycine-Generating Enzyme-Like Proteins Constitute a Novel Family of Widespread Type VI Secretion System Immunity Proteins. Journal of Bacteriology, Vol. 203, No. 21
Fridman, C.M., Keppel, K., Gerlic, M. et al. A comparative genomics methodology reveals a widespread family of membrane-disrupting T6SS effectors. Nat Commun 11, 1085 (2020). 14951-4
Jana, B., Fridman, C.M., Bosis, E. et al. A modular effector with a DNase domain and a marker for T6SS substrates. Nat Commun 10, 3595 (2019).
Dar, Y.; Salomon, D.; Bosis, E. The Antibacterial and Anti-Eukaryotic Type VI Secretion System MIX-Effector Repertoire in Vibrionaceae. Mar. Drugs 2018, 16, 433.
Teper D, Girija AM, Bosis E, Popov G, Savidor A, et al. (2018) The Xanthomonas euvesicatoria type III effector XopAU is an active protein kinase that manipulates plant MAP kinase signaling. PLOS Pathogens 14(1): e1006880.
Merda, D, Briand, M, Bosis, E, et al. Ancestral acquisitions, gene flow and multiple evolutionary trajectories of the type three secretion system and effectors in Xanthomonas plant pathogens. Mol Ecol. 2017; 26: 5939– 5952.

מענקים ופרסים | Grants and Awards

שנת המענק: 2021

הקרן הלאומית למדע ISF

איפיון מחלקה חדשה ונפוצה של אפקטורים רב־צורתיים במערכת הפרשה מטיפוס 6

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